![]() ![]() Median time from randomization to data cutoff (January 6, 2020) was 29.5 months (range 24.6-37.3). The Japanese subgroup comprised 94 patients (pembrolizumab-axitinib, n = 44 sunitinib, n = 50 11% of the intent-to-treat population). Objective response rate (ORR) and safety were secondary endpoints. Dual primary endpoints were OS and PFS as assessed by blinded independent central review. Adults with clear cell mRCC were randomly assigned 1:1 to receive intravenous pembrolizumab 200 mg every 3 weeks plus oral axitinib 5 mg twice daily or oral sunitinib 50 mg once daily (4 weeks on/2 weeks off). Patients enrolled in Japan were included in this post hoc subgroup analysis. KEYNOTE-426 evaluated patients enrolled from 25 sites in Japan. In the phase III open-label KEYNOTE-426 ( NCT02853331) study, first-line pembrolizumab and axitinib improved overall survival (OS) and progression-free survival (PFS) versus sunitinib for metastatic renal cell carcinoma (mRCC). 17 Kindai University, 3 Chome-4-1 Kowakae, Higashiosaka, Osaka, 577-8502, Japan.16 Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr #1710, Nashville, TN, 37232, USA.15 Cleveland Clinic Taussig Cancer Institute, CA Building, 10201 Carnegie Ave, Cleveland, OH, 44106, USA. ![]() 14 MSD K.K., Kitanomaru Square, 1 Chome-13-12 Kudankita, Chiyoda City, Tokyo, 102-0073, Japan.13 Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.12 Yamaguchi University, 1-1-1, Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.11 Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.10 University of Tsukuba, 1 Chome-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.9 Sapporo Medical University, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan.8 Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.7 Niigata University Medical & Dental Hospital, 1-757 Asahimachi, Chuou-ku, Niigata, 951-8510, Japan.6 Nara Medical University Hospital, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.5 Nippon Medical School Hospital, 1-1-5 Sendagi Bunkyo, Tokyo, 113-8603, Japan.4 Keio University Hospital, Shinanomachi, Shinjuku City, Tokyo, 〒160-8582, Japan.3 National Cancer Center Hospital East, 6 Chome Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.2 Toranomon Hospital, 2 Chome-2-2 Toranomon, Minato City, Tokyo, 105-8470, Japan. 1 Bell Land General Hospital, Higashiyama 500-3, Naka-ku, Sakai, Osaka, 599-8247, Japan. ![]()
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